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Published on: June 4, 2020
Impact of Handgrip Strength on Clinical Outcomes after Percutaneous Coronary Intervention
Akihiro Tobe1, Akihito Tanaka1, Yoshinori Shirai1
1Department of Cardiology, Nagoya University Graduate School of Medicine.
Insights
Low handgrip strength (HGS) is linked to worse clinical outcomes in patients undergoing percutaneous coronary intervention (PCI). This study found low HGS independently predicts adverse events post-PCI, highlighting its prognostic value.
Area of Science:
- Cardiology
- Clinical Outcomes
- Predictive Biomarkers
Background:
- Handgrip strength (HGS) is a measure of muscle function.
- Its association with clinical outcomes after percutaneous coronary intervention (PCI) is not well-established.
- Assessing HGS may offer insights into patient prognosis following PCI.
Purpose of the Study:
- To investigate the relationship between HGS and clinical outcomes in patients undergoing PCI.
- To determine if low HGS is an independent predictor of adverse events after PCI.
Main Methods:
- A single-center observational study included 469 patients who underwent PCI.
- Patients were categorized into low HGS and high HGS groups based on sex-specific thresholds.
- The primary outcome was a composite of all-cause death, myocardial infarction, and heart failure readmission.
Main Results:
- The low HGS group (n=151) was older and had lower body mass index and serum albumin levels compared to the high HGS group (n=318).
- During a median follow-up of 778 days, the low HGS group exhibited a significantly higher incidence of the composite endpoint.
- Low HGS was identified as an independent predictor for the composite endpoint (HR 1.80, 95% CI 1.04-3.12, p=0.04).
Conclusions:
- Low handgrip strength is independently associated with adverse clinical outcomes after percutaneous coronary intervention.
- HGS may serve as a valuable prognostic marker in patients undergoing PCI.
Aim:
The relationship between handgrip strength (HGS) and clinical outcomes after percutaneous coronary intervention (PCI) has not yet been thoroughly investigated.
Methods:
This was a single-center, observational study. A total of 469 patients who underwent PCI and whose periprocedural HGS was measured were included. Patients were divided into two groups: the low HGS group (men, ＜28 kg; women, ＜18 kg) and the high HGS group (men, ≥ 28 kg; women, ≥ 18 kg). The primary outcome was the composite endpoint of all-cause death, myocardial infarction (MI), and heart failure readmission.
Results:
There were 151 patients in the low HGS group and 318 patients in the high HGS group. The age of patients in the low HGS group was significantly higher (median [interquartile range]: 78 [71-82] vs. 70 [61-75] years, p＜0.001), while the body mass index and serum albumin level were significantly lower (body mass index: 22.5 [20.2-24.3] vs. 24.3 [22.3-26.6] kg/m2, p＜0.001; serum albumin: 3.6 [3.1-3.9] vs. 4.0 [3.7-4.3] g/dL, p＜0.001) than those in the high HGS group. During the median follow-up period of 778 days, the low HGS group had a higher incidence of composite endpoint than the high HGS group (p＜0.001). The low HGS group had a higher risk of all-cause, cardiac, and non-cardiac death (p＜0.001). Multivariable Cox proportional hazards analysis showed that low handgrip strength was an independent predictor for the composite endpoint (hazard ratio 1.80, 95% confidence interval 1.04-3.12, p=0.04).
Conclusions:
Low HGS was independently associated with adverse outcomes after PCI.
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