Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

110
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
110
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

194
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
194
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

34.9K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
34.9K
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

207
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
207

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Climatic Influence on COVID-19: Investigating the Role of Temperature and Humidity in the Spread of the Omicron Variant.

GeoHealth·2026
Same author

Retraction Note: Daylight saving time affects European mortality patterns.

Nature communications·2026
Same author

REPLY TO: "Daylight Saving Time and Mortality-Proceed with Caution "in response to "Daylight saving time affects European mortality patterns" by Levy et al.

Nature communications·2026
Same author

Projecting climate change impacts on health: A tutorial integrating the latest climate and demographic scenarios.

Environmental epidemiology (Philadelphia, Pa.)·2026
Same author

Disentangling urban vulnerability to rising temperatures.

The Lancet. Planetary health·2026
Same author

The 2026 Europe report of the Lancet Countdown on health and climate change: narrowing window for decisive health action.

The Lancet. Public health·2026

Related Experiment Video

Updated: Aug 22, 2025

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

8.6K

Daylight saving time affects European mortality patterns.

Laurent Lévy1, Jean-Marie Robine2,3, Grégoire Rey4

  • 1Medical School of the University of Geneva, Geneva, Switzerland.

Nature Communications
|November 13, 2022
PubMed
Summary

Daylight saving time (DST) shifts impact mortality. While spring transitions may slightly decrease deaths, fall transitions show an increase in mortality during the initial two weeks, alongside a year-round weekly pattern.

More Related Videos

An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research
06:16

An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research

Published on: February 2, 2022

2.5K
Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.1K

Related Experiment Videos

Last Updated: Aug 22, 2025

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

8.6K
An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research
06:16

An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research

Published on: February 2, 2022

2.5K
Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.1K

Area of Science:

  • Chronobiology
  • Public Health
  • Epidemiology

Background:

  • Daylight saving time (DST) involves a one-hour clock shift twice annually.
  • DST can cause circadian misalignment, potentially affecting health and safety.
  • The population-level impact of DST on mortality patterns is not well understood.

Purpose of the Study:

  • To investigate the effect of DST transitions on all-cause mortality.
  • To analyze mortality dynamics in European populations following DST shifts.
  • To identify any weekly mortality patterns associated with DST.

Main Methods:

  • Analysis of all-cause mortality data from 16 European countries (1998-2012).
  • Examination of mortality rates in the weeks following spring and fall DST transitions.
  • Investigation of mortality patterns aligned with DST transition dates and weekly cycles.

Main Results:

  • Mortality showed a decrease in the spring following DST and an increase in the fall.
  • These mortality changes were observed during the first two weeks post-transition.
  • A consistent weekly mortality pattern (lowest on Sundays, highest on Mondays) was found, persisting year-round.

Conclusions:

  • DST transitions are associated with short-term fluctuations in population mortality.
  • The fall DST transition appears to be linked to an increased mortality risk.
  • A persistent weekly mortality rhythm exists, independent of DST and seasonal changes, particularly in older adults.