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Reliable and High Efficiency Extraction of Kidney Immune Cells
Published on: August 19, 2016
Intermediate monocytes expansion and homing markers expression in COVID-19 patients associate with kidney dysfunction
Chiara Dentone1, Daniela Fenoglio2,3, Alessia Parodi2
1Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy. chiaradentone@libero.it.
Abstract:
Patients with severe SARS-CoV-2 infection have an overwhelming inflammatory response characterized by remarkable organs monocyte infiltration. We performed an immunophenotypic analysis on circulating monocytes in 19 COVID-19 patients in comparison with 11 naïve HIV-1 patients and 10 healthy subjects. Reduced frequency of classical monocytes and increased frequency of intermediate monocytes characterized COVID-19 patients with respect to both HIV naïve patients and healthy subjects. Intensity of C-C motif chemokine receptor 2 (CCR2) monocyte expression highly correlated with parameters of kidney dysfunction. Our data indicate that highly activated monocytes of COVID-19 patients may be pathogenically associated with the development of renal disease.
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