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Published on: May 3, 2019
Current State of 44Ti/44Sc Radionuclide Generator Systems and Separation Chemistry
Christine E Schmidt1,2, Leah Gajecki3, Melissa A Deri1,2
1Department of Chemistry, Graduate Center of the City University of New York, New York, NY 10016, USA.
Abstract:
In recent years, there has been an increased interest in 44Ti/44Sc generators as an onsite source of 44Sc for medical applications without needing a proximal cyclotron. The relatively short half-life (3.97 hours) and high positron branching ratio (94.3%) of 44Sc make it a viable candidate for positron emission tomography (PET) imaging. This review discusses current 44Ti/44Sc generator designs, focusing on their chemistry, drawbacks, post-elution processing, and relevant preclinical studies of the 44Sc for potential PET radiopharmaceuticals.
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