Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same journal

Laboratory Codes in Nomenclature and Scientific Communication (Advancing Organism Nomenclature in Scientific Communication to Improve Research Reporting and Reproducibility).

ILAR journal·2022

Same journal

History of the National Academies of Sciences, Engineering, and Medicine's Institute for Laboratory Animal Research.

ILAR journal·2022

Same journal

History of the International Council for Laboratory Animal Science.

ILAR journal·2022

Same journal

International Standardized Nomenclature for Outbred Stocks of Laboratory Animals.

ILAR journal·2022

Same journal

Rapid Response by Laboratory Animal Research Institutions During the COVID-19 Pandemic: Key Lessons Learned From a 2021 National Academies of Sciences, Engineering, and Medicine Workshop.

ILAR journal·2022

Same journal

Beyond the Laboratory: Emerging Landscape of Animal Studies - the Influence of National Academies of Sciences Activities and Publications.

ILAR journal·2022

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Manual Restraint and Common Compound Administration Routes in Mice and Rats

Manual Restraint and Common Compound Administration Routes in Mice and Rats

Published on: September 26, 2012

Guide for Laboratory Animal Facilities and Care.

|November 14, 2022

Summary

The Animal Care Panel promotes scientific exchange and high standards for laboratory animal care through resources, training, and publications. It collaborates with key organizations to improve animal welfare in research settings.

Area of Science:

Veterinary Science
Animal Welfare
Scientific Publishing

Background:

The Animal Care Panel is a nonprofit organization dedicated to advancing the care and study of laboratory animals.
Membership includes individuals and institutions across the United States and internationally.
The Panel focuses on the production, care, and study of animals used in research.

Purpose of the Study:

To facilitate the exchange of scientific information on all aspects of laboratory animal care.
To establish and promote high standards for laboratory animal facilities and care.
To support advancements in laboratory animal welfare and quality.

Main Methods:

Disseminating information on laboratory animal handling films.
Developing and implementing an animal technician training program.

More Related Videos

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Published on: October 3, 2016

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Published on: August 21, 2021

Related Experiment Videos

Last Updated: Jul 3, 2026

Manual Restraint and Common Compound Administration Routes in Mice and Rats

Manual Restraint and Common Compound Administration Routes in Mice and Rats

Published on: September 26, 2012

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Published on: October 3, 2016

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Published on: August 21, 2021

Publishing a bimonthly journal, "Laboratory Animal Care."

Sponsoring annual awards for outstanding contributions to animal care.

Maintaining liaison with key organizations in the field.

Gathering and examining information via the Animal Facilities Standards Committee.

Main Results:

Established a platform for scientific information exchange.
Initiated a training program for animal technicians.
Published a dedicated journal for laboratory animal care.
Recognized achievements in animal care through awards.
Contributed to the development of standards for animal facilities.

Conclusions:

The Animal Care Panel plays a vital role in advancing laboratory animal science and welfare.
Collaboration and information sharing are crucial for maintaining high standards in animal care.
The Panel's initiatives have led to improved practices and quality in laboratory animal research.