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Updated: Aug 22, 2025

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae
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Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Published on: April 30, 2018

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Clinical aspects of decidualization

Vilmos Fülöp1,2,3, Kornél Lakatos2,3, János Demeter1

  • 11 Magyar Honvédség Egészségügyi Központ, Szülészet-nőgyógyászati Osztály Budapest Magyarország.

Orvosi Hetilap
|November 14, 2022
PubMed

An essential component of successful conception and pregnancy is decidualization, which involves structural and functional transformation of the endometrium. The process involves structural changes in the uterine mucosa, transformation of spiral arterioles, numerical and functional adaptation of leukocytes in the endometrium and their subsequent migration, and functional and morphological changes in decidual stromal cells. As part of decidualization, trophoblast cells of embryonic origin perform a physiological invasion of maternal tissue to create the placenta. The success of the process is due to the special antigenicity of the trophoblast cells and the immune communication between the graft (fetus) and the host (mother) through hormones, cytokines and multiple receptorligand connections. Disorders of these processes are the basis of several diseases that threaten conception, implantation, and successful pregnancy, such as recurrent miscarriage, preeclampsia, intrauterine retardation, or preterm birth. In this article, we review the anatomical, immunological, and molecular basis of physiological decidualization to address common disorders in the clinical practice of obstetrics that are related to a dysfunctional decidualization.

Keywords:
anyai-magzati immuntoleranciadecidualizationdecidualizációfetal programingfetal-maternal immune toleranceinfertilityinfertilitásmagzati programozástrophoblast invasiontrophoblastinvázió

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