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Ankle Joint

Ankle Joint

The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...

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Related Experiment Video

Updated: Aug 22, 2025

A Mouse Model of Ankle-Subtalar Complex Joint Instability

A Mouse Model of Ankle-Subtalar Complex Joint Instability

Published on: October 28, 2022

A Mouse Model of Ankle-Subtalar Complex Joint Instability.

Shuo Wang¹, Peixin Liu¹, Chunzhuo Hua¹

¹Department of Orthopaedics, The First Affiliated Hospital of Soochow University; Orthopaedic Institute, Soochow University.

Journal of Visualized Experiments : Jove

|November 14, 2022

Summary

Researchers developed a mouse model for ankle-subtalar complex joint (ASCJ) instability, a common sports injury. This model aids in understanding injury mechanisms and developing better treatments for ankle sprains and post-traumatic osteoarthritis.

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Area of Science:

Orthopedics
Sports Medicine
Biomechanical Engineering

Background:

Ankle sprains are common sports injuries leading to ankle-subtalar complex joint (ASCJ) instability.
ASCJ instability can cause post-traumatic osteoarthritis (PTOA) and lacks clear diagnostic and treatment consensus.
Mouse hindfoot anatomy is similar to humans, making it suitable for modeling human joint injuries.

Purpose of the Study:

To establish and validate a mouse model for ASCJ instability.
To provide a preclinical tool for studying the mechanisms and consequences of ankle sprains.
To facilitate the development of improved clinical treatments for ASCJ injuries.

Main Methods:

Ligamentous transection around the ASCJ in mice to induce instability.
Behavioral tests: balance beam, footprint analysis, thermal nociception assessment.
Histological analyses: micro-CT scanning and articular cartilage staining.

Main Results:

A validated mouse model of ASCJ instability was successfully created.
The model demonstrated measurable changes in balance, locomotion, and sensory function.
Histological analysis confirmed joint damage and cartilage degeneration consistent with instability.

Conclusions:

The established mouse model effectively replicates ASCJ instability seen in human ankle sprains.
This model serves as a valuable preclinical tool for investigating injury mechanisms.
It will aid in the development of novel therapeutic strategies for ankle sprains and PTOA.