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MR1: An unconventional twist in the tail
Prabhjeet Phalora1, Paul Klenerman1
1Nuffield Department of Medicine, University of Oxford, Oxford, UK.
The Journal of Cell Biology
|November 14, 2022
Abstract:
MR1 is a conserved molecule that binds microbial vitamin B metabolites and presents them to unconventional T cells. Lim and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202110125) uncover the role of AP2 in ensuring MR1 surface presentation, which relies on an atypical motif within the MR1 cytoplasmic tail.
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