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Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Engineering Multishelled Nanostructures Enables Stepwise Self-Degradability for Drug-Release Optimization.

Bei-Bei Yan1, Yang Zhao1, Menghuan Li2

  • 1Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, People's Republic of China.

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Hierarchically structured silica nanoparticles offer controlled drug release for tumor therapy. These degradable nanoparticles stabilize drug concentration, reducing health risks and improving treatment efficacy.

Keywords:
chemotherapydegradability controldrug release regulationmultishelled nanospheresnanostructure design

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Achieving a balance between degradability and controlled drug release is critical for effective drug delivery systems.
  • Existing systems face challenges in sequential degradation and tunable release kinetics.

Purpose of the Study:

  • To develop hierarchically structured nanoparticles with tunable degradation and drug release properties.
  • To investigate the potential of these nanoparticles for sustained drug delivery in tumor therapy.

Main Methods:

  • Fabrication of multishelled silica nanoparticles using an amorphous calcium carbonate template.
  • Characterization of nanoparticle structure, sequential degradation, and drug release kinetics.
  • Evaluation of nanoparticle concentration effects on hydrolysis and drug release.

Main Results:

  • Hierarchically structured nanoparticles exhibited sequential degradation.
  • Drug release rate was inversely correlated with nanoparticle concentration due to a shielding effect.
  • High nanoparticle doses resulted in low drug release, stabilizing local drug concentration for tumor therapy.
  • Complete degradation of nanoparticles was observed, potentially minimizing health risks.

Conclusions:

  • Multishelled silica nanoparticles serve as sustainable drug depots.
  • The tunable degradation and release kinetics offer a novel approach for tumor treatment.
  • This nanostructure provides a new avenue for developing advanced drug delivery systems.