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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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Psychedelic-Assisted Therapy for People with Eating Disorders.

Natalie Gukasyan1, Colleen C Schreyer2, Roland R Griffiths3

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Psychedelic-assisted therapy (PAT) shows promise for treating eating disorders, including anorexia nervosa. While research is ongoing, PAT may enhance current treatments for these complex conditions.

Keywords:
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Area of Science:

  • Psychiatry
  • Psychopharmacology
  • Mental Health

Background:

  • Emerging research indicates psychedelic-assisted therapy (PAT) may offer safe and effective treatments for various mental health conditions.
  • Eating disorders are a recent focus of interest for PAT interventions.
  • Anorexia nervosa is a primary focus of this review regarding PAT.

Purpose of the Study:

  • To provide an updated summary of the potential mechanisms of PAT in individuals with eating disorders.
  • To review the current use of PAT for eating disorders, with a specific emphasis on anorexia nervosa.

Main Methods:

  • This review synthesizes recent findings on psychedelic-assisted therapy for eating disorders.
  • Focus on mechanisms of action and clinical trial data.

Main Results:

  • Classic psychedelics may possess transdiagnostic efficacy relevant to eating disorder pathology.
  • Interest and access efforts for PAT are increasing.
  • Early clinical trials are evaluating PAT safety and utility, but efficacy is not yet established.
  • High-quality data supporting PAT for eating disorders is still limited.
  • Recent studies suggest PAT could augment existing treatments for difficult-to-treat eating disorders.

Conclusions:

  • Psychedelic-assisted therapy presents a potential novel treatment avenue for eating disorders.
  • Further high-quality research is needed to clarify the efficacy and safety of PAT in this population.
  • PAT may serve as an adjunctive therapy to improve outcomes for individuals with anorexia nervosa and other eating disorders.