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Related Concept Videos

Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

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Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
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Active Ingredients of Reduning Injection Maintain High Potency against SARS-CoV-2 Variants.

Zhen Xiao1,2, Huan Xu3, Ze-Yang Qu1,2

  • 1Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.

Chinese Journal of Integrative Medicine
|November 14, 2022
PubMed
Summary
This summary is machine-generated.

Quercetin and luteolin in Reduning Injection show strong anti-coronavirus potential, inhibiting SARS-CoV-2 and its variants. Their mechanisms involve binding to viral proteins, suggesting Reduning Injection as a promising COVID-19 treatment.

Keywords:
Chinese medicineReduning injectionSARS-CoV-2luteolinquercetin

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Area of Science:

  • Virology
  • Pharmacology
  • Drug Discovery

Background:

  • Coronaviruses, including SARS-CoV-2, pose significant global health threats.
  • Reduning Injection is a traditional Chinese medicine formulation used for viral infections.
  • Quercetin and luteolin are key active compounds within Reduning Injection.

Purpose of the Study:

  • To investigate the anti-coronavirus activity of quercetin and luteolin.
  • To elucidate the underlying mechanisms of their antiviral action.
  • To assess their potential as therapeutic agents for COVID-19.

Main Methods:

  • Utilized a pseudovirus system to evaluate the efficacy of quercetin and luteolin against SARS-CoV-2 and its variants.
  • Employed virtual screening and surface plasmon resonance (SPR) to identify viral protein binding sites.
  • Assessed inhibition of HCoV-OC43 using indirect immunofluorescence assays.

Main Results:

  • Luteolin and quercetin demonstrated dose-dependent inhibition of SARS-CoV-2 pseudovirus with low EC50 values.
  • Luteolin effectively blocked entry of SARS-CoV-2 variants, while both compounds showed high inhibition against HCoV-OC43.
  • Virtual screening and SPR confirmed luteolin binds to S-proteins and quercetin binds to 3CLpro, PLpro, and helicase proteins.

Conclusions:

  • The study reveals the mechanisms by which quercetin and luteolin inhibit coronavirus infections.
  • These compounds exhibit significant antiviral activity, supporting their role in Reduning Injection.
  • Reduning Injection shows promise as a therapeutic option for COVID-19 and related viral infections.