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Published on: September 25, 2019
Exosomes in HBV infection
Ziyu Liu1, Yanan Li2, Yufeng Wang3
1Pediatric Respiratory Department, First Hospital of Jilin University, Changchun, Jilin 130021, China; School of Life Science, Jilin University, Changchun, Jilin 130021, China.
Abstract:
Exosomes have been identified as important mediators of intercellular communication in several physiological and pathological processes. Hepatitis B is caused by infection with the hepatitis B virus (HBV), which impairs hepatocytes, with chronic infection resulting in cirrhosis or liver cancer. We studied the roles and functions of exosomes in HBV infection and found that exosomes could promote HBV spread and development of HBV-related diseases. Exosomes could be used as potential biomarkers for HBV diagnosis. Furthermore, exosomes have potential applications in treatment for HBV infection via inhibition of HBV replication and transcription.
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