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Related Experiment Video

Updated: Aug 22, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Injectable polylysine and dextran hydrogels with robust antibacterial and ROS-scavenging activity for wound healing.

Rong Yang1, Wenliang Xue1, Huiyun Liao2

  • 1State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.

International Journal of Biological Macromolecules
|November 14, 2022
PubMed
Summary

This study developed a new injectable hydrogel dressing from polylysine-graft-cysteine and oxidized dextran. This advanced wound dressing promotes skin regeneration by exhibiting antibacterial, antioxidant, and self-healing properties.

Keywords:
AntibacterialAntioxidantInjectable hydrogelSelf-healingWound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing

Background:

  • Cutaneous wound management faces challenges from inflammation and infection.
  • Hydrogel dressings with antibacterial and antioxidant properties are needed for effective wound healing.

Purpose of the Study:

  • To fabricate a multifunctional hydrogel for promoting skin tissue regeneration.
  • To create an injectable and self-healing hydrogel with antibacterial and antioxidant capabilities.

Main Methods:

  • Fabrication of a hydrogel using polylysine-graft-cysteine (EPL-SH) and oxidized dextran (ODex).
  • Characterization of hydrogel properties including gelation time, rheology, swelling, degradation, injectability, and self-healing.
  • Evaluation of antioxidant, antimicrobial, and cell affinity properties.
  • In vivo assessment of full-thickness skin defects in animal models.

Main Results:

  • The EPL-SH/ODex hydrogel exhibited tunable gelation, suitable swelling/degradation, and injectability/self-healing.
  • The hydrogel demonstrated significant antioxidant, antimicrobial, and tissue adhesive properties.
  • In vivo studies showed enhanced collagen deposition and angiogenesis, promoting wound healing.

Conclusions:

  • The developed multifunctional hydrogel dressing offers a promising strategy for enhancing cutaneous wound treatment.
  • This injectable hydrogel promotes skin regeneration through combined antibacterial, antioxidant, and tissue-engineering benefits.