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Related Concept Videos

Decreased pulse rate01:14

Decreased pulse rate

589
Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
589
ECG Interpretation of Arrhythmias I: Sinus Arrhythmias01:16

ECG Interpretation of Arrhythmias I: Sinus Arrhythmias

307
Arrhythmias are disturbances in the heart's rhythm that lead to abnormal heartbeats. These irregularities can originate from different parts of the heart and are classified based on their origin and nature.
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
307
Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

Dysrhythmias IV: Characteristics of Bradyarrhythmias

20
Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
20
Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers01:27

Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers

926
β-receptor blockers significantly impact the cardiovascular system by counteracting catecholamine-induced sympathetic responses. These medications decrease heart rate, contractility, and cardiac output, potentially leading to cardiac depression, life-threatening bradycardia, and death. Therapeutically, β-blockers function as mild antihypertensives and are utilized in treating angina pectoris and cardiac arrhythmias. However, nonselective β-blockers inhibit β2-receptors in...
926
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

357
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
357
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers01:24

Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers

818
Adrenergic stimulation generally impacts cardiac rate and rhythm. Specifically, stimulation of the β-adrenoceptors triggers an increase in intracellular calcium ion influx and pacemaker currents, which may cause arrhythmias. Catecholamines like adrenaline also demonstrate β2-adrenoceptor-mediated hypokalemia, impacting cardiac action potential and disrupting the normal cardiac rhythm. Class II antiarrhythmic drugs are β-adrenoceptor antagonists or β-blockers, which...
818

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Related Experiment Video

Updated: Aug 22, 2025

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
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Hydrocortisone-induced symptomatic sinus bradycardia.

Mohammed Ahmed1, Success Tobore Oyibo1, Shailesh Dalvi1

  • 1Department of Cardiology, Betsi Cadwaladr University Health Board, Wrexham, Gwynedd, UK.

BMJ Case Reports
|November 14, 2022
PubMed
Summary
This summary is machine-generated.

High-dose steroids, like hydrocortisone, can rarely cause severe bradycardia (slow heart rate). This side effect resolved after stopping the medication, emphasizing the need for cardiac monitoring in patients on pulsed steroid therapy.

Keywords:
ArrhythmiasCardiovascular medicineCardiovascular systemCrohn's disease

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Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Steroids are widely prescribed but associated with diverse adverse effects.
  • Bradycardia is a rare but serious adverse effect of steroid therapy.
  • Few documented cases link steroid use to bradycardia.

Observation:

  • A woman in her 50s experienced severe symptomatic sinus bradycardia.
  • The bradycardia occurred after high-dose intravenous hydrocortisone for Crohn's disease exacerbation.
  • Symptoms resolved completely upon steroid discontinuation.

Findings:

  • Pulsed high-dose hydrocortisone can induce severe sinus bradycardia.
  • Steroid-induced bradycardia is reversible upon cessation of the drug.
  • This case adds to the limited literature on steroid-associated cardiac events.

Implications:

  • Baseline electrocardiogram (ECG) and cardiac monitoring are crucial for patients receiving pulsed high-dose steroids.
  • Clinicians should be vigilant for cardiac side effects, including bradycardia, during high-dose steroid treatment.
  • Further research may elucidate the mechanisms underlying steroid-induced bradycardia.