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Comparative Sedation with Sevoflurane and Thiopental in Children Undergoing MR Imaging

Nurettin Kurt1, Duygu Karakose Caliskan2, Haci Yusuf Gunes1

  • 1Department of Anaesthesiology and Reanimation, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|November 15, 2022
PubMed

Insights

This study compared propofol and thiopental for pediatric MRI sedation. Propofol was associated with higher apnea/desaturation rates, while thiopental led to more bradycardia, indicating different risk profiles for pediatric sedation.

Area of Science:

  • Anesthesiology and Critical Care
  • Pediatric Imaging and Sedation

Background:

  • Sedation is crucial for pediatric patients undergoing MRI.
  • Propofol and thiopental are common induction agents.
  • Sevoflurane is frequently used for maintenance anesthesia.

Purpose of the Study:

  • To compare the efficacy and safety of propofol versus thiopental for sedation in pediatric patients undergoing MRI.
  • To analyze demographic data, comorbidities, and anesthetic/recovery times.
  • To identify and compare complications associated with each induction agent.

Main Methods:

  • A descriptive, comparative study included 1222 pediatric patients undergoing MRI.
  • Patients were divided into two groups: Group I (Propofol, aged 2-18 years) and Group II (Thiopental, <2 years).
  • All patients received Sevoflurane insufflation post-induction; data on demographics, ASA scores, anesthetic times, and complications were recorded.

Main Results:

  • Group I patients were older, heavier, and had higher ASA scores than Group II.
  • Certain comorbidities like epilepsy and autism were more prevalent in Group I.
  • Apnea and desaturation were higher in the propofol group (Group I), while bradycardia was more frequent in the thiopental group (Group II).

Conclusions:

  • Sevoflurane insufflation is safe for pediatric patients post-induction with either propofol or thiopental.
  • Both propofol and thiopental can be safely used for pediatric MRI sedation, with distinct complication profiles.
  • Anesthesiologists should consider patient age and comorbidities when selecting an induction agent.
Abstract

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