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Leptin and Hyperlipidemia in Primigrivida Preeclamptic Women and Normotensive Women

Mehwish Rana1, Bushra Iftikhar2, Saba Khaliq1

  • 1Department of Physiology, University of Health Sciences, Lahore, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|November 15, 2022
PubMed

Insights

Serum leptin levels were significantly higher in primigravida women with preeclampsia (PE) compared to normotensive women. This finding suggests leptin may play a role in PE development.

Area of Science:

  • Reproductive Endocrinology
  • Clinical Biochemistry
  • Maternal-Fetal Medicine

Background:

  • Preeclampsia (PE) is a serious pregnancy complication.
  • Leptin, a hormone regulating appetite and metabolism, is implicated in cardiovascular function.
  • Understanding biochemical markers in PE is crucial for early detection and management.

Purpose of the Study:

  • To compare serum leptin and lipid profiles in primigravida women with and without preeclampsia.
  • To investigate potential correlations between leptin levels and preeclampsia in first-time mothers.

Main Methods:

  • An analytical cross-sectional study was conducted between 2018-2020.
  • Serum leptin levels were measured using ELISA in preeclamptic (n=?) and normotensive (n=?) primigravida women (30-36 weeks gestation).
  • Lipid profiles and complete blood counts were also analyzed.

Main Results:

  • Mean serum leptin levels were significantly elevated in the preeclamptic group (33.44±12.91 ng/ml) compared to the normotensive group (4±6.20 ng/ml).
  • Statistical significance was observed (p < [value not provided]).
  • Lipid profile parameters were also assessed, but specific findings are not detailed in the abstract.

Conclusions:

  • Elevated serum leptin levels are associated with preeclampsia in primigravida women.
  • Leptin may serve as a potential biomarker for preeclampsia.
  • Further research is warranted to explore the role of leptin in PE pathophysiology.
Abstract

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