Related Experiment Video
Updated: Aug 21, 2025

Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta
Published on: June 10, 2015
A genomic deep field view of hypertension
Pranav S Garimella1, Clea du Toit2, Nhu Ngoc Le2
1Division of Nephrology and Hypertension, University of California San Diego, San Diego, California, USA.
None:
Blood pressure is regulated by a complex neurohumoral system including the renin-angiotensin-aldosterone system, natriuretic peptides, endothelial pathways, the sympathetic nervous system, and the immune system. This review charts the evolution of our understanding of the genomic basis of hypertension at increasing resolution over the last 5 decades from monogenic causes to polygenic associations, spanning ∼30 monogenic rare variants and >1500 single nucleotide variants. Unexpected early wins from blood pressure genomics include deepening of our understanding of the complex causation of hypertension; refinement of causal estimates bidirectionally between blood pressure, risk factors, and outcomes through Mendelian randomization; risk stratification using polygenic risk scores; and opportunities for precision medicine and drug repurposing.
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Hypertension and Regulation of Blood Pressure
Hypertension II: Pathophysiology
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension I: Introduction

