Related Experiment Video

Updated: Aug 21, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

19.9K

Role of Hedgehog and Hippo signaling pathways in cancer: A special focus on non-coding RNAs

Uttam Sharma1, Hardeep Singh Tuli2, Vivek Uttam2

  • 1Department of Zoology, Central University of Punjab, Ghudda 151 401, Bathinda, Punjab, India.

Pharmacological Research
|November 15, 2022
PubMed

Insights

Non-coding RNAs (ncRNAs) like miRNAs, lncRNAs, and circRNAs regulate cancer pathways. Targeting these ncRNAs and their interactions with Hedgehog and Hippo pathways offers potential for novel cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer mortality remains high despite advances in treatment.
  • Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are critical regulators of cellular processes.
  • The Hedgehog (Hh) and Hippo signaling pathways are frequently dysregulated in cancer.

Approach:

  • This review synthesizes current research on how ncRNAs modulate the Hh and Hippo signaling pathways in various cancers.
  • It examines the crosstalk between these pathways and their role in therapeutic resistance.
  • The review also explores the potential of phytochemicals in regulating these pathways for cancer treatment.

Key Points:

  • ncRNAs directly target key molecules within the Hh and Hippo pathways, presenting opportunities for targeted cancer therapies.
  • The Hh and Hippo pathways exhibit crosstalk via Gli1 and YAP1/TEAD, influencing cancer progression.
  • These pathways contribute to resistance against chemotherapy, radiotherapy, and immunotherapy by affecting GLI and YAP/TAZ protein levels.

Conclusions:

  • Understanding the intricate roles of ncRNAs in Hh and Hippo signaling is crucial for developing effective cancer treatments.
  • Phytochemicals demonstrate potential in modulating these pathways, paving the way for new drug development.
  • Targeting ncRNAs and their associated signaling pathways offers a promising avenue for overcoming therapeutic resistance and improving patient outcomes.
Keywords:
CancerCircular RNADrugHedgehogHippoLncRNAsMiRNAsNon-coding RNASignaling pathways

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