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Updated: Aug 21, 2025

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions
Published on: May 27, 2021
Calnexin reveals a sugar-free taste within the lipid bilayer
Kevin P Guay1,2, Robert V Williams1, Daniel N Hebert1,2
1Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA, USA.
Abstract:
Maturation of membrane proteins is complicated by the need to fold in three distinct environments. While much is known about folding in the two aqueous milieus constituted by cytoplasm and ER lumen, our knowledge of the folding, arrangement, and quality control of transmembrane regions within the lipid bilayer, and its facilitation by molecular chaperones, is limited. New work by Bloemeke et al now reveals an expanded role of the ER chaperone calnexin acting within the lipid bilayer in a carbohydrate-independent manner.
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