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Updated: Aug 19, 2026

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Detection of Rare Mutations in CtDNA Using Next Generation Sequencing
Published on: August 24, 2017
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Truncal Dynamics May Trump: Serial ctDNA to Predict Early Therapeutic Response
Madhulika Eluri1, Scott Kopetz2, Christine M Parseghian2
1Department of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Abstract
Summary:
Promising utility of using serial ctDNA in metastatic colorectal cancer to both refine patient selection, reduce toxicity due to chemotherapy, and to evaluate emerging resistance mechanisms may lead the way to novel therapeutic strategies. However, important questions remain in validating its use as a predictive biomarker of treatment response. See related article by Vidal et al., p. 379.

