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Updated: Aug 21, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Management of paroxysmal nocturnal hemoglobinuria (PNH)
1Department of Haematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania.
Abstract:
PNH is a chronic hemolytic disorder due to an intrinsic red cell abnormality. There is no evidence that either prolonged administration of corticosteroids or chemotherapy are beneficial in PNH. On the other hand, patients can live with PNH for many years with supportive management. At the moment complement inhibitor therapy is indicated in most cases; and it is highly desirable that the current financial barriers to this therapy be overcome.
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