Related Experiment Video
Updated: Aug 21, 2025
07:23
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
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Anti-Vascular Endothelial Growth Factor Treatment Patterns and Outcomes in Retinal Vein Occlusion in Routine Clinical
Ophthalmic Surgery, Lasers & Imaging Retina
|November 15, 2022
Summary
Treatment frequency for retinal vein occlusion (RVO)-related macular edema (ME) varies significantly in clinical practice. This heterogeneity did not impact long-term visual acuity or retinal thickness outcomes.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Medical Practice
Background:
- Retinal vein occlusion (RVO) can lead to macular edema (ME), impacting vision.
- Understanding treatment patterns is crucial for managing RVO-ME.
- Current clinical practice shows varied anti-VEGF injection frequencies.
Purpose of the Study:
- To characterize anti-VEGF treatment patterns for RVO-ME in routine clinical practice.
- To assess the impact of these treatment patterns on long-term visual acuity and retinal thickness.
Main Methods:
- Retrospective study of 365 eyes with RVO-related ME (2003-2020).
- Analysis of treatment intervals and factors influencing them.
- Subgroup analysis comparing outcomes across different injection intervals.
Main Results:
- Significant heterogeneity in anti-VEGF injection frequency observed for both branch RVO (BRVO) and central/hemi-RVO (CRVO/HRVO).
- Age, diabetes, and baseline central subfield thickness (CST) predicted maintenance injection intervals (MII).
- No significant differences in best-corrected visual acuity (BCVA) or CST at 12 and 24 months across different MII groups.
Conclusions:
- Anti-VEGF treatment frequency for RVO-ME exhibits considerable variation in clinical practice.
- Despite treatment heterogeneity, long-term visual and anatomical outcomes were comparable across different injection intervals.
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