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Related Concept Videos

Brain Imaging01:14

Brain Imaging

279
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
279

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Protocol for the Tessa Jowell BRAIN MATRIX Platform Study.

Colin Watts1,2, Joshua Savage3, Amit Patel3

  • 1Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK C.Watts.2@bham.ac.uk.

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|November 15, 2022
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Summary
This summary is machine-generated.

The Tessa Jowell BRAIN MATRIX Platform (TJBM) study establishes a UK research infrastructure for glioma, improving patient treatment through integrated diagnostic data. This patient-centric approach aims to advance glioma knowledge and clinical trials.

Keywords:
clinical trialsneurological oncologyneurosurgery

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Area of Science:

  • Neuro-oncology
  • Genomics
  • Clinical Research Infrastructure

Background:

  • Gliomas are common primary central nervous system (CNS) tumors with significant mortality.
  • The WHO classification (since 2016) integrates molecular data for more accurate CNS tumor subtyping.
  • There is a need for advanced clinical research infrastructure to support patient-centric glioma studies.

Purpose of the Study:

  • To establish a transformative clinical research infrastructure for glioma studies in the UK.
  • To improve knowledge and treatment for patients with glioma.
  • To create a patient-centric platform attractive to academic and commercial investors.

Main Methods:

  • A platform study collecting clinical, imaging, and pathology data from glioma patients.
  • Utilizing whole-genome sequencing and epigenomic classification for integrated diagnosis.
  • Targeting recruitment of 1000 patients with interim analyses at 100 and 500 patients.

Main Results:

  • The primary outcome is the time from biopsy to integrated histological-molecular diagnosis.
  • Secondary outcomes focus on process, patient, and framework measures.
  • Interim analyses will provide early insights into study progress.

Conclusions:

  • The TJBM platform study will generate a comprehensive data repository for glioma research.
  • This infrastructure will facilitate improved understanding and treatment of gliomas.
  • The study adheres to ethical guidelines and promotes open dissemination of results.