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Lentiviral Mediated Production of Transgenic Mice: A Simple and Highly Efficient Method for Direct Study of Founders
Published on: October 7, 2018
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Novel methods for the generation of genetically engineered animal models
Annelise Cassidy1, Melda Onal2, Stephane Pelletier1
1Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.
Bone
|November 15, 2022
Summary
New genome editing technologies enable precise and rapid generation of genetically modified mouse models for studying bone and skeletal muscle biology, overcoming limitations of older methods.
Area of Science:
- Genetics and Genomics
- Molecular Biology
- Physiology
Background:
- Genetically modified mouse models are crucial for understanding biological systems.
- Traditional methods like transgenesis and ES cell gene replacement are imprecise and costly.
- Recent advances offer improved precision and efficiency in genome engineering.
Conclusions:
- Modern genome editing technologies revolutionize the creation of mouse models.
- Precise genetic manipulation facilitates deeper understanding of physiological and pathological conditions.
- This review highlights strategies for studying bone and skeletal muscle biology using advanced mouse models.
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