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Prevalence, Risk Factors, and Outcomes of Gout Flare in Patients Hospitalized for PCR-Confirmed COVID-19: A

Kanon Jatuworapruk1, Panchalee Satpanich2, Philip C Robinson3

  • 1K. Jatuworapruk, MD, PhD, Faculty of Medicine, Thammasat University, Pathumthani, Thailand; kanon@tu.ac.th.

The Journal of Rheumatology
|November 15, 2022
PubMed

Insights

Gout flare occurred in 18% of hospitalized COVID-19 patients with gout, increasing hospital stays by 3 days. Suboptimal urate-lowering therapy (ULT) increases the risk of gout flare during coronavirus disease 2019 hospitalization.

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Internal Medicine

Background:

  • Gout is a common inflammatory arthritis. Coronavirus disease 2019 (COVID-19) can trigger various inflammatory responses.
  • Understanding the interplay between gout and COVID-19 is crucial for managing patients with both conditions.

Purpose of the Study:

  • To determine the prevalence and outcomes of gout flare in patients hospitalized with COVID-19.
  • To identify factors associated with gout flare and its impact on hospital length of stay.

Main Methods:

  • Retrospective cohort study of adult patients with comorbid gout hospitalized for COVID-19.
  • Analysis of gout flare prevalence, characteristics, and outcomes.
  • Statistical analysis using logistic regression and linear regression to identify associated factors and impact on hospital stay.

Main Results:

  • Gout flare occurred in 18% of patients with comorbid gout hospitalized for COVID-19.
  • Patients with gout flare had higher serum urate and lower use of urate-lowering therapy (ULT).
  • Gout flare was associated with an increased hospital length of stay by 3 days.

Conclusions:

  • Gout flare is a significant complication in hospitalized COVID-19 patients with gout.
  • Suboptimal ULT is a risk factor for gout flare during COVID-19 hospitalization.
  • Managing gout effectively may reduce complications and hospital stay in these patients.
Abstract

Keywords:
COVID-19SARS-CoV-2goutgouty arthritishospitalization

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