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Updated: Aug 21, 2025

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
Published on: August 20, 2021
Fast and accurate mapping of long reads to complete genome assemblies with VerityMap
Andrey V Bzikadze1, Alla Mikheenko2, Pavel A Pevzner3
1Graduate Program in Bioinformatics and Systems Biology, University of California, San Diego, California 92093, USA.
Abstract:
Recent advancements in long-read sequencing have enabled the telomere-to-telomere (complete) assembly of a human genome and are now contributing to the haplotype-resolved complete assemblies of multiple human genomes. Because the accuracy of read mapping tools deteriorates in highly repetitive regions, there is a need to develop accurate, error (detecting potential assembly errors), and diploide (distinguishing different haplotypes) tools for read mapping in complete assemblies. We describe the first accurate, error-exposing, and partially diploid-aware VerityMap tool for long-read mapping to complete assemblies.
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