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Updated: Aug 21, 2025

Underwater Endoscopic Injection Sclerotherapy for Gastroesophageal Varices
Published on: August 1, 2025
Cap-assisted endoscopic sclerotherapy is effective for rectal mucosal prolapse associated outlet obstructive
Tianyu Liu1, Suyu He2, Qianlong Li2
1Department of Endoscopic Center of Suining Central Hospital, Sichuan, PR China; Department of Unit 4 of Gastroenterology of Suining Central Hospital, Sichuan, PR China.
Cap-assisted endoscopic sclerotherapy (CAES) effectively treats outlet obstructive constipation (OOC) caused by internal hemorrhoids (IH) and rectal mucosal prolapse (RMP). This minimally invasive treatment significantly improves OOC symptoms, bowel function, and associated anxiety and depression.
Area of Science:
- Gastroenterology
- Colorectal Surgery
- Endoscopic Procedures
Background:
- Outlet obstructive constipation (OOC) is a prevalent form of chronic constipation often linked to internal hemorrhoids (IH) and rectal mucosal prolapse (RMP).
- Cap-assisted endoscopic sclerotherapy (CAES) has shown promise in managing IH and RMP, suggesting potential for OOC treatment.
Purpose of the Study:
- To evaluate the efficacy of Cap-assisted endoscopic sclerotherapy (CAES) in treating patients with outlet obstructive constipation (OOC) associated with internal hemorrhoids (IH) and rectal mucosal prolapse (RMP).
Main Methods:
- Thirty-one patients diagnosed with OOC underwent CAES for IH and RMP.
- Anorectal manometry (AM), Wexner constipation score (WCS), self-rating anxiety scale (SAS), and self-rating depression scale (SDS) were assessed pre- and post-treatment.
- Follow-up assessments were conducted to evaluate treatment outcomes.
Main Results:
- CAES significantly improved subjective measures including bowel movement frequency, defecation time, WCS, SAS, and SDS.
- Anorectal manometry revealed significant improvements in anal relaxation rate, maximum squeeze pressure, and rectal residual pressure post-CAES.
- The proportion of patients with Bristol stool form scale types III-V increased substantially, indicating improved stool consistency.
Conclusions:
- Cap-assisted endoscopic sclerotherapy (CAES) demonstrates significant efficacy in treating outlet obstructive constipation (OOC) stemming from internal hemorrhoids (IH) and rectal mucosal prolapse (RMP).
- Successful OOC symptom management through CAES correlates with notable improvements in psychological well-being, specifically reducing anxiety and depression.
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