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Related Concept Videos

Regression Toward the Mean01:52

Regression Toward the Mean

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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
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Related Experiment Video

Updated: Aug 21, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study.

Pengsheng Li1,2, Haiyan Wang1,2,3, Lan Guo4

  • 1Foshan Fetal Medicine Research Institute, Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University, Foshan, China.

BMC Medicine
|November 16, 2022
PubMed
Summary

This study investigated the causal link between gut microbiota and preeclampsia. Bifidobacterium was found to have a protective effect against preeclampsia, suggesting potential probiotic benefits.

Keywords:
Causal inferenceEclampsiaGut microbiotaMendelian randomization studyPreeclampsia

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Area of Science:

  • Microbiome Research
  • Genetics
  • Obstetrics

Background:

  • Observational studies suggest a link between gut microbiota and preeclampsia.
  • The causal relationship between gut microbiota and preeclampsia-eclampsia remains unclear.

Approach:

  • A two-sample Mendelian randomization study utilized large-scale genome-wide association study data for gut microbiota and preeclampsia-eclampsia.
  • Multiple statistical methods, including inverse variance weighted and MR-Egger, were employed to assess causality.
  • Reverse Mendelian randomization was conducted to confirm directional effects.

Key Points:

  • Bifidobacterium showed a significant protective association with preeclampsia-eclampsia (OR=0.76, P=8.03 × 10⁻⁴).
  • Several other bacteria, including Collinsella and Enterorhabdus, exhibited suggestive associations.
  • No significant reverse causal effect of preeclampsia-eclampsia on gut microbiota was detected.

Conclusions:

  • Bifidobacterium is causally associated with a reduced risk of preeclampsia-eclampsia.
  • Further research, including randomized controlled trials, is warranted to confirm the protective role of probiotics and elucidate their mechanisms.