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Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
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Vinculin phosphorylation impairs vascular endothelial junctions promoting atherosclerosis

Yu-Tsung Shih1, Shu-Yi Wei1, Jin-Hua Chen2

  • 1Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli 35053, Taiwan.

European Heart Journal
|November 16, 2022
PubMed
Summary

Disturbed blood flow causes vinculin phosphorylation (VCLS721p), promoting atherosclerosis. Inhibiting this pathway and targeting VCLS721p offers new therapeutic strategies for vascular disease.

Keywords:
AtherosclerosisDisturbed flowEndothelial cellPhosphoproteomicsShear stressVinculin

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