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MMN and P3a Elicited by a Novelty Oddball Paradigm Are Not Reduced in Early-Phase Psychosis
Hayley Riel1, Erica Rudolph2, Catrina MacPhee1
1Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Introduction:
The present study compared the mismatch negativity (MMN) and P3a waveforms among early-phase psychosis (EPP; n = 13) individuals and healthy controls (n = 30) to contribute to the research on these waveforms as potential biomarkers for schizophrenia.
Methods:
MMN and P3a were elicited with a novelty paradigm using complex stimuli with electrophysiological technology.
Results:
No significant group differences of amplitude were observed with either waveform. Increased asociality and blunted affect were associated with a reduction in both MMN and P3a waveforms indicating a relationship between these negative symptoms and cognitive deficits. Good social and occupational functioning correlated with improved MMN and P3a waveforms in the EPP group.
Conclusions:
This study suggests that MMN and P3a may be more appropriately used as an indicator of illness progression and symptomology rather than a biomarker in the early phase of the illness.
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