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Regulated cell death: Implications for intervertebral disc degeneration and therapy
Fan Yang1, Weijian Liu1, Yongcan Huang2
1Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal of Orthopaedic Translation
|November 16, 2022
Summary
Regulated cell death (RCD) plays a key role in intervertebral disc degeneration (IDD). Understanding RCD mechanisms and interactions is crucial for developing new therapies to treat chronic low back pain caused by IDD.
Area of Science:
- Cell Biology
- Biomedical Science
- Regenerative Medicine
Background:
- Intervertebral disc degeneration (IDD) is a primary cause of chronic low back pain.
- Regulated cell death (RCD) is implicated in IDD pathogenesis, but its initiation, progression, and interplay between modes are poorly understood.
Purpose of the Study:
- To synthesize current research on RCD modes in IDD.
- To identify research gaps and preclinical strategies for alleviating IDD and promoting disc repair by targeting RCD.
Main Methods:
- Comprehensive literature search using keywords 'regulated cell death' and 'intervertebral disc degeneration' in major scientific databases (PubMed, Embase, Web of Science).
- Review and synthesis of relevant findings on RCD mechanisms and therapeutic strategies in IDD.
Main Results:
- Multiple RCD modes are present in intervertebral discs during IDD.
- Factors like mechanical stress, inflammation, and nutritional imbalance induce RCD in disc cells.
- Interactions between different RCD modes during IDD progression are complex and not fully elucidated.
Conclusions:
- Understanding the fundamental mechanisms and interactions of RCD modes in IDD is essential for developing effective therapeutic strategies.
- Targeting RCD holds promise for rescuing disc degeneration and advancing clinical treatments for chronic low back pain.
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