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A Long-Lasting Skin Protectant Based on CG-101, a Deep Eutectic Solvent Comprising Choline and Geranic Acid
Marina Shevachman1,2, Abhirup Mandal1,2, Kevin Gelston1,2
1CAGE Bio Inc 733 Industrial Road San Carlos CA 94070 USA.
Global Challenges (Hoboken, NJ)
|November 16, 2022
Summary
A new skin protectant, CG-101, offers long-lasting antimicrobial protection for hours, unlike short-lived alcohol-based hand sanitizers. This novel formulation provides a safer, more effective alternative for maintaining hygiene and preventing infectious disease spread.
Area of Science:
- Microbiology
- Dermatology
- Public Health
Background:
- The COVID-19 pandemic highlighted the critical need for effective hygiene solutions.
- Frequent handwashing, while recommended, is often impractical.
- Existing alcohol-based hand sanitizers offer only short-term protection due to rapid evaporation.
Purpose of the Study:
- To develop and evaluate a novel, long-lasting skin protectant.
- To assess the antimicrobial efficacy and safety of the new formulation.
- To compare its performance against conventional hand sanitizers.
Main Methods:
- Formulation of a novel skin protectant (CG-101) using biocompatible ionic liquid/deep eutectic solvents (choline and geranic acid).
- In vitro testing against bacteria and human coronavirus (hCoV229E).
- Human clinical studies to evaluate skin irritation, sensitization, and duration of protection.
Main Results:
- CG-101 demonstrated in vitro inactivation of bacteria and hCoV229E for up to 4 hours.
- Clinical studies confirmed CG-101 is non-irritating and non-sensitizing to the skin.
- A single application of CG-101 provided significantly longer-lasting microbial protection compared to ethanol-based sanitizers.
Conclusions:
- CG-101 represents a novel, long-lasting skin protectant with potential as a superior alternative to alcohol-based hand sanitizers.
- The formulation offers extended antimicrobial defense, addressing limitations of current hygiene practices.
- Further research may establish CG-101 as a key tool in managing infectious disease transmission.
Keywords:
SARS‐CoV‐2alcohol‐based hand sanitizercoronavirusextended protectionhand hygienepandemicskin protectantMore Related Videos
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