Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Burn Injuries01:22

Burn Injuries

2.7K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.7K
Disorders of Hemostasis01:24

Disorders of Hemostasis

1.1K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.1K
Coagulation01:09

Coagulation

7.2K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
7.2K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

8.8K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
8.8K
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

19
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
19
Introduction to Hemostasis01:05

Introduction to Hemostasis

8.6K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bibliometric analysis of alternative performance metrics for peri-operative, critical care and pain medicine journals.

Anaesthesia·2021
Same author

Pleuropericardial Cyst Mimicking a Metastasis of Differentiated Thyroid Carcinoma on Whole-Body Iodine-131 Scan: a Case Report.

Nuclear medicine and molecular imaging·2019
Same author

The role of Apigenin in testicular damage in experimental ischemia-reperfusion injury in rats.

Hippokratia·2016
Same author

Maternal and umbilical cord oxygen content and acid-base balance in relation to general, epidural or subarachnoid anesthesia for term elective cesarean section.

Clinical and experimental obstetrics & gynecology·2013
Same author

Transcranial Doppler monitoring of middle cerebral flow velocity in a patient with a ventriculoperitoneal shunt undergoing laparoscopy.

Journal of clinical monitoring and computing·2012
Same author

Is expansion of artificial dermis a reliable reconstructive option?

Annals of burns and fire disasters·2012
Same journal

Isolated Deep Thermal Burns of the Dorsal Foot Treated by Excision and Split-Thickness Skin Grafting at the Burn Centre of Lille: Characteristics, Surgical Management and Healing Delay.

Annals of burns and fire disasters·2026
Same journal

Self-Esteem and Social Support: Predictors of Psychological Well-Being in Severe Burn Survivors.

Annals of burns and fire disasters·2026
Same journal

Efficacy of Collagen Dressing for Scald Burn Among the Paediatric Population.

Annals of burns and fire disasters·2026
Same journal

Annals of burns and fire disasters·2026
Same journal

Mortality Analysis of ICU Burn Patients in Indonesia's National Referral Hospital: A 2-Year Retrospective Study.

Annals of burns and fire disasters·2026
Same journal

Epidemiology and Risk Factors of Burn Injuries During the Cold Season in a Regional Hospital in Northeast Thailand: A Retrospective Study.

Annals of burns and fire disasters·2026
See all related articles

Related Experiment Video

Updated: Aug 21, 2025

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
02:49

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes

Published on: February 23, 2024

1.2K

Coagulation Disorders And Mortality In Burn Injury: A Systematic Review.

E Nikolaidou1, D Kakagia2, E Kaldoudi2

  • 1General Hospital of Thessaloniki "G. Papanikolaou", Thessaloniki, Greece.

Annals of Burns and Fire Disasters
|November 16, 2022
PubMed
Summary
This summary is machine-generated.

Coagulopathy significantly impacts burn injury outcomes and mortality. Newer viscoelastic coagulation assays (VCAs) are better than standard tests for assessing burn patients

Keywords:
burncoagulationcoagulopathymortalitysystematic review

More Related Videos

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
07:45

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

9.8K
Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

12.6K

Related Experiment Videos

Last Updated: Aug 21, 2025

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
02:49

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes

Published on: February 23, 2024

1.2K
Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
07:45

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

9.8K
Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

12.6K

Area of Science:

  • Trauma and Burn Surgery
  • Hematology
  • Critical Care Medicine

Background:

  • Coagulopathy is common in trauma but its role in burn injury is not well understood.
  • Existing literature on coagulation assays in burn patients is inconsistent.
  • Early identification of coagulopathy is crucial for managing burn severity and predicting outcomes.

Purpose of the Study:

  • To review literature on burn patient characteristics and coagulation markers in the early post-burn period.
  • To evaluate the role of different coagulation assays in predicting mortality in burn patients.
  • To assess the utility of standard and viscoelastic coagulation assays (VCAs) in burn care.

Main Methods:

  • Comprehensive literature search across multiple databases (PubMed, Scopus, etc.).
  • Inclusion of studies on adult burn patients within 24 hours of admission, assessing coagulation and mortality.
  • Adherence to PRISMA guidelines for evidence-based review.

Main Results:

  • Eleven studies met eligibility criteria, confirming a strong link between coagulopathy and burn injury mortality.
  • Standard coagulation assays are insufficient for detecting rapid hemostatic changes in burn patients.
  • Viscoelastic coagulation assays (VCAs) show promise for more accurate assessment.

Conclusions:

  • Coagulopathy is definitively linked to burn injury and significantly impacts patient mortality.
  • Rapid hemostatic changes in burn patients necessitate advanced diagnostic tools.
  • Routine use of VCAs is recommended for comprehensive coagulopathy assessment and knowledge standardization in burn care.