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Published on: August 19, 2020
Development of crescentic membranoproliferative glomerulonephritis after COVID-19 vaccination
Gabor Göndör1, Sara H Ksiazek1, Heinz Regele2
1Department of Medicine VI with Nephrology and Dialysis, Clinic Ottakring, Vienna, Austria.
Abstract:
Membranoproliferative glomerulonephritis (MPGN) comprises a histologic pattern of glomerular injury with different underlying diseases. Here we report on a 47-year-old female with rapidly progressive glomerulonephritis (RPGN) on top of a previously diagnosed idiopathic MPGN after receiving the first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) mRNA vaccine. After aggressive immunosuppression her serum creatinine returned to normal values, along with reduction of proteinuria. Recently, numerous publications have reported an association of glomerular diseases with COVID-19 vaccination. Our case presents to the best of our knowledge the first occurrence of possible association of COVID-19 mRNA vaccination with a crescentic form of MPGN.
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