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Related Concept Videos

Infertility in Females01:28

Infertility in Females

375
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
375
Infertility in Males01:23

Infertility in Males

316
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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In Vitro Fertilization01:24

In Vitro Fertilization

361
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Nondisjunction01:21

Nondisjunction

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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
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Related Experiment Video

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Mouse Round Spermatid Injection
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Oncofertility in pediatric patients: current perspectives.

Rafael Marques1, Maria João Oura2, Rita Dionísio3

  • 1Centro Hospitalar Entre o Douro e Vouga, Santa Maria da Feira, Portugal.

Contemporary Oncology (Poznan, Poland)
|November 16, 2022
PubMed
Summary

Oncofertility addresses cancer patients' concerns about future reproductive ability. Fertility preservation options are crucial for childhood cancer survivors, requiring shared decisions at diagnosis.

Keywords:
cancerfertilityfertility preservation techniquesoncofertilitypediatric cancer patients

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Area of Science:

  • Reproductive medicine
  • Oncology
  • Pediatric oncology

Background:

  • Cancer treatments can impact fertility and reproductive health.
  • Oncofertility is an emerging field addressing these concerns.
  • Fertility preservation is vital for childhood cancer survivors' quality of life.

Purpose of the Study:

  • Define oncofertility and its scope.
  • Examine cancer/treatment effects on pediatric fertility and mental health.
  • Detail fertility preservation options and barriers.

Main Methods:

  • Literature review on oncofertility and pediatric cancer.
  • Analysis of fertility preservation techniques.
  • Discussion of psychological impacts and decision-making.

Main Results:

  • Oncofertility integrates cancer care with reproductive health.
  • Cancer therapies pose risks to fertility and mental well-being.
  • Diverse fertility preservation methods exist, tailored by gender and pubertal status.

Conclusions:

  • Oncofertility care is essential for pediatric cancer patients.
  • Early, shared decision-making regarding fertility preservation is critical.
  • Multidisciplinary teams can mitigate barriers to fertility preservation.