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Updated: Aug 21, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Contemporary and future invasive coronary vasomotor function testing and treatment in patients with ischaemia with no
Peter Damman1, Suzette E Elias-Smale1, Tijn P J Jansen1
1Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Insights
This review highlights the crucial role of diagnostics and therapy for patients with ischaemia with no obstructive coronary arteries (INOCA). It details the coronary function test (CFT) and future diagnostic and treatment strategies for INOCA.
Area of Science:
- Cardiology
- Vascular Medicine
- Diagnostic Imaging
Background:
- Ischaemia with no obstructive coronary arteries (INOCA) presents diagnostic challenges.
- Accurate diagnosis and effective therapy are vital for managing INOCA patients.
Purpose of the Study:
- To review the importance of diagnostics and therapy in INOCA.
- To discuss the diagnostic coronary function test (CFT) and its future advancements.
- To outline current and future treatment strategies for INOCA.
Main Methods:
- Review of current literature on INOCA diagnostics and therapeutics.
- Description of the diagnostic coronary function test (CFT) procedure.
- Discussion of emerging technologies like angiography-derived physiology and invasive continuous thermodilution.
Main Results:
- The coronary function test (CFT) is a key diagnostic procedure for INOCA.
- Future diagnostic tools will enhance the understanding and identification of INOCA phenotypes.
- Comprehensive treatment strategies are essential for improving patient outcomes.
Conclusions:
- Effective INOCA management requires a focus on both diagnostics and therapy.
- Advancements in diagnostic procedures like CFT are crucial for personalized INOCA care.
- National registration and further research into pathophysiology will improve INOCA understanding and treatment.
Abstract:
In the current review, we emphasize the importance of diagnostics and therapy in patients with ischaemia with no obstructive coronary arteries (INOCA). The importance of the diagnostic coronary function test (CFT) procedure is described, including future components including angiography-derived physiology and invasive continuous thermodilution. Furthermore, the main components of treatment are discussed. Future directions include the national registration ensuring a high quality of INOCA care, besides a potential source to improve our understanding of pathophysiology in the various phenotypes of coronary vascular dysfunction, the diagnostic CFT procedure, and treatment.
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