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Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

635
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
635
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

921
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
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Atherosclerosis III: Management01:26

Atherosclerosis III: Management

19
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
19
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

219
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
219
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

31
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
31
Lipid Digestion01:06

Lipid Digestion

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Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
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Related Experiment Video

Updated: Aug 21, 2025

Cholesterol Efflux Assay
07:54

Cholesterol Efflux Assay

Published on: March 6, 2012

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World Heart Federation Cholesterol Roadmap 2022.

Kausik K Ray1, Brian A Ference2,3, Tania Séverin4

  • 1Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, Reynolds Building, St. Dunstans Road, London, GB.

Global Heart
|November 16, 2022
PubMed
Summary
This summary is machine-generated.

Preventing atherosclerotic cardiovascular diseases (ASCVD) requires early interventions, affordable treatments, and improved health systems globally. This roadmap outlines strategies to overcome cholesterol management barriers and reduce ASCVD burden.

Keywords:
ASCVDcholesterolfamilial hypercholesterolaemialipid lowering therapylow-density lipoprotein cholesterol prevention

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Last Updated: Aug 21, 2025

Cholesterol Efflux Assay
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High-throughput Nitrobenzoxadiazole-labeled Cholesterol Efflux Assay
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Area of Science:

  • Cardiovascular Medicine
  • Public Health
  • Health Systems Research

Background:

  • Atherosclerotic cardiovascular diseases (ASCVD) are a leading global cause of premature death and healthcare costs.
  • Preventing cholesterol accumulation in blood vessels is key to ASCVD prevention.
  • Novel therapies and updated concepts offer new opportunities for ASCVD prevention.

Approach:

  • Reviewed guidelines and research since 2017.
  • Consulted experts in dyslipidemia management and health systems in low- and middle-income countries (LMICs).
  • Identified key principles, implementation gaps, health system roadblocks, and strategies for ASCVD prevention.

Key Points:

  • Focus on primordial prevention, affordable cholesterol testing, and universal screening for inherited dyslipidemias.
  • Utilize lifetime risk assessment and ensure access to affordable, potent statins and combination therapies.
  • Enhance health literacy, multidisciplinary teams, risk quantification tools, and therapy adherence.

Conclusions:

  • ASCVD is preventable through life-course strategies targeting atherosclerosis at all stages.
  • Updated preventive strategies should integrate health policy, lifestyle changes, and early pharmacotherapy.
  • Investment in early prevention is crucial to preserve cardiovascular health over treating ASCVD consequences.