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Advances in multi-omics study of biomarkers of glycolipid metabolism disorder

Xinyi Fang1,2, Runyu Miao1,2, Jiahua Wei3

  • 1Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.

Computational and Structural Biotechnology Journal
|November 16, 2022
PubMed

Keywords:
1,5-AG, 1,5-anhydroglucitol2-AAA, 2-aminoadipic acid2-DGE, two-dimensional gel electrophoresisABCC8, ATP binding cassette subfamily C member 8ADA, American Diabetes AssociationAhR, aromatic hydrocarbon receptorBA, bile acidBCAA, branched-chain amino acidBCKAs, branched chain keto acidsBiomarkersCE, cholesterol esterCFL1, cofilin-1CRP, C reactive proteinCYP450, cytochrome P450DAG, diacylglycerolDPP-4, dipeptyl peptidase 4EASD, European Association for the Study of DiabetesFA, fatty acidFFA, free fatty acidFMT, fecal microbiota transplantationFTO, fat mass and obesity-associatedGAS5, growth arrest-specific transcript 5GC–MS/MS, gas chromatography-tandem mass spectrometryGLP-1, glucagon-like peptide 1GLP-1R, glucagon-like peptide 1 receptorGSIS, glucose-stimulated insulin secretionGWAS, genome-wide association studyGlycolipid metabolism disorderHGF, hepatocyte growth factorHMG-CoA, hydroxymethylglutaryl-coenzyme AHMGCR, 3-hydroxy-methylglutaryl coenzyme A reductaseHPLC, high performance liquid chromatographyHbA1C, glycylated hemoglobinIL-1ra, interleukin-1 receptor antagonistIMP, imidazole propionateIR, insulin resistanceJNK, c-Jun-N-terminal-kinaseKCNJ11, potassium inwardly rectifying channel subfamily J member 11L-GPC, linoleoyl-glycerophosphocholineLC-MS/MS, liquid chromatography-tandem mass spectrometryLPC, lysophosphatidylcholineLPE, lysophosphatidylethanolaminesLPS, lipopolysaccharideMAPK, mitogen-activated protein kinaseMASP, mannose-binding lectin-associated serine protease 1MATE1, multidrug and toxin extrusion protein 1MDR1, multidrug resistance mutation 1MGT, magnesium transporterMS, Mass SpectrometryMechanism studyMulti-omicsNK, natural killerNMR, nuclear magnetic resonanceOCT, organic cationic transporterOGTT, oral glucose tolerance testPC-PL, phosphatidylcholine-plasmalogenPE, phosphatidylethanolaminesPNPLA3, patatin-like phospholipase domain-containing protein 3PPAR, peroxisome proliferator-activated receptorPTBP1, polypyrimidine tract-binding protein 1PTP, protein tyrosine phosphataseRNS, reactive nitrogen speciesROS, reactive oxygen speciesSCFA, short-chain fatty acidSLC30A8, solute carrier family 30 member 8SLC47A1, solute carrier family 47 member 1SLC5A2, solute carrier family 5 member 2SM, sphingomyelinSNP, single-nucleotide polymorphismSSPG, steady-state plasma glucoseSUR1, sulfonylurea receptor 1T2DM, type 2 diabetes mellitusTAG, triacylglycerolTCA, tricarboxylic acidTCF7L2, transcription factor 7-like 2TF, transcription factorTMA, trimethylamineTMAO, trimethylamine oxideTNF-α, tumor necrosis factor alphaTOF-MS, time-of-flight mass spectrumTUG1, taurine upregulated gene 1USP20, ubiquitin-specificpeptidase 20WBC, white blood cellcircRNA, circular RNAhADCS, human adipose-derived stem cellshsCRP, high-sensitivity C-reactive proteinlnc-BATE1, brown adipose tissue enriched long non-coding RNA 1lncRNA SHGL, lncRNA suppressor of hepatic gluconeogenesis and lipogenesislncRNA, long non-coding RNAmRNA, messenger RNAsmTORC1, mechanistic target of rapamycin complex 1miRNA, micro RNAncRNA, non-coding RNAt-PA, tissue plasminogen activatorα-HB, α-hydroxybutyrate

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