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Updated: Aug 21, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
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Published on: December 19, 2020

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Clinical characteristics among patients with COVID‑19: A single‑center retrospective study

Anjum Farhana1, Bilal Ahmad Tantry1, Naveed Nazir Shah2

  • 1Department of Microbiology, Government Medical College, Srinagar, Jammu and Kashmir 190010, India.

Biomedical Reports
|November 16, 2022
PubMed

Insights

Severe coronavirus disease 2019 (COVID-19) cases show distinct clinical and laboratory features. Key indicators include specific symptoms, elevated inflammatory markers like C-reactive protein (CRP) and interleukin-6 (IL-6), and lymphopenia.

Area of Science:

  • Infectious Diseases
  • Clinical Medicine
  • Biochemistry

Background:

  • Coronavirus disease 2019 (COVID-19) is a global health crisis.
  • Understanding clinical and laboratory differences between severe and non-severe cases is crucial for patient management.

Purpose of the Study:

  • To investigate the clinical features and laboratory parameters of hospitalized COVID-19 patients.
  • To differentiate characteristics between severe and non-severe COVID-19 cases.

Main Methods:

  • Retrospective analysis of clinical data from 1,096 hospitalized COVID-19 patients.
  • Categorization into severe (626 patients) and non-severe (470 patients) groups.
  • Statistical analysis using chi-square and Mann-Whitney U tests to compare groups.

Main Results:

  • Severe COVID-19 cases presented with anosmia, sore throat, fatigue, headache, and shortness of breath.
  • Significantly elevated C-reactive protein (CRP) and interleukin-6 (IL-6) levels were observed in severe cases.
  • Hypertension was a more frequent comorbidity in severe COVID-19 patients, alongside significant lymphopenia.

Conclusions:

  • Hospitalized patients with severe COVID-19 exhibit notable clinical symptoms and laboratory abnormalities.
  • Elevated inflammatory markers (CRP, IL-6) and lymphopenia are key indicators of disease severity.
  • Hypertension is a significant comorbidity associated with severe COVID-19 outcomes.

Keywords:
D-dimerc-reactive proteinscomorbidity and inflammationcoronavirus disease 2019interleukin 6lactate dehydrogenaselymphopenia

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