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Therapeutic approaches to combat the global antibiotic resistance challenge

Nabeela Farhat1, Asad U Khan1

  • 1Medical Microbiology & Molecular Biology Lab, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India.

Future Microbiology
|November 16, 2022
PubMed

Insights

Antimicrobial resistance (AMR) is a growing threat. Combinational antibiotic therapy offers a promising strategy to overcome bacterial resistance mechanisms, with synergy testing guiding effective treatment options.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Antimicrobial resistance (AMR) poses a significant global health threat, driven by emerging resistant markers like carbapenemases.
  • Healthcare professionals face increasing challenges in treating infections caused by resistant bacteria.

Purpose of the Study:

  • To review therapeutic strategies for combating AMR, focusing on bacterial resistance mechanisms.
  • To explore the potential of combinational antibiotic therapy in overcoming AMR.
  • To discuss methods for testing antibiotic synergy.

Main Methods:

  • Literature review of studies on antimicrobial resistance and combinational antibiotic therapy.
  • Analysis of bacterial resistance mechanisms susceptible to combined treatments.
  • Evaluation of synergy testing methodologies.

Main Results:

  • Combinational antibiotic therapy presents a viable approach to manage AMR.
  • Specific resistance mechanisms can be effectively targeted by certain antibiotic combinations.
  • Synergy testing is crucial for identifying effective combination regimens.

Conclusions:

  • Combinational antibiotic therapy is a key strategy for mitigating the threat of AMR.
  • Further detailed study of antibiotic combinations and synergy testing is warranted.
  • Integrating diverse approaches is essential for developing effective AMR interventions.
Keywords:
antimicrobial resistancebacteriophage therapycombinational therapyefflux pumpefflux pump inhibitorsenzymatic destructionporinvaccineβ-lactamaseβ-lactamase inhibitor

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