Proximity-driven bioorthogonal reactions via DNA circuits enable the accurate aptasensing of non-nucleic acid targets
Su-Jing Zhao1, Haiyu Guo1, Zhenkun Wu1
1State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. tomwu@hnu.edu.cn.
Abstract:
Tetrazine-mediated bioorthogonal reactions were rationally coupled with DNA cascade circuits to enable proximal decaging, which allowed the construction of a fluorogenic aptasensor for the accurate and amplified sensing of non-nucleic acid targets in live cells.
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