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The organelle-specific signaling sequences direct proteins synthesized in the cytosol to their final destination like ER, mitochondria, peroxisomes, etc. Some of the proteins directed to ER are then trafficked via vesicles to other organelles within the cell or the extracellular environment through the Golgi complex. For example, the rough ER synthesizes soluble proteins for transportation to the lysosomes or secretion out of the cell. It can also synthesize transmembrane proteins that can...
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Choreographing the motor-driven endosomal dance.

Marlieke L M Jongsma1, Nina Bakker1, Jacques Neefjes1

  • 1Department of Cell and Chemical Biology, ONCODE institute, Leiden University Medical Center LUMC, 2333 ZC Leiden, The Netherlands.

Journal of Cell Science
|November 16, 2022
PubMed
Summary
This summary is machine-generated.

Motor proteins dynein and kinesin coordinate endosomal transport along cellular microtubules. Understanding their interactions reveals how endosomes move, mature, and communicate within the cell.

Keywords:
DynactinDyneinEndoplasmic reticulumEndosomesKinesinMembrane contact sitesMicrotubules

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Area of Science:

  • Cell Biology
  • Molecular Motors
  • Intracellular Transport

Background:

  • The endosomal system is crucial for cellular transport, involving lipid, protein, and nutrient trafficking.
  • Endosomes undergo maturation, shape changes (fusion/fission), and organelle communication.
  • Their movement is complex, featuring bidirectional and stop-and-go dynamics.

Approach:

  • This review comprehensively examines the regulation of motor protein interactions with endosomes and microtubules.
  • Focuses on the roles of dynein and kinesin motor proteins in endosomal mobility.
  • Investigates how cargo-binding and motor domains mediate these interactions.

Key Points:

  • Dynein and kinesin motors link endosomal subtypes to microtubule tracks.
  • Interactions are mediated by motor protein domains binding to endosome-associated and microtubule-associated proteins.
  • These molecular interactions dictate the specific movements of endosomal structures.

Conclusions:

  • The coordinated action of motor proteins is essential for the precise choreography of endosomal transport.
  • Understanding these regulatory factors provides insight into the dynamic behavior of endosomes.
  • This knowledge is key to deciphering the intricate dance of endosomes along cellular highways.