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Roles of m6A modification in oral cancer (Review)

Huimin Liu1, Yinyu Wang2, Tianyi Xue3

  • 1Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China.

International Journal of Oncology
|November 16, 2022
PubMed

Insights

N6-methyladenosine (m6A) RNA modification influences oral cancer progression and impacts treatment strategies. Targeting m6A offers new therapeutic avenues for oral cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Oral cancer presents a significant challenge due to complex pathogenic mechanisms and poor prognosis.
  • RNA modifications, particularly N6-methyladenosine (m6A), are increasingly recognized for their role in various diseases, including cancer.

Approach:

  • This review analyzes the multifaceted roles of m6A modification in oral cancer.
  • It examines the impact of m6A on cancer cell proliferation, apoptosis, migration, and invasion.
  • The review also explores m6A's involvement in chemotherapy resistance and its potential in immunotherapy.

Key Points:

  • m6A modification is a prevalent RNA modification affecting gene expression and cellular processes.
  • Dysregulation of m6A impacts oral cancer cell behavior, including proliferation and metastasis.
  • m6A levels are implicated in resistance to chemotherapy and hold potential for immunotherapy strategies.

Conclusions:

  • m6A modification represents a critical factor in the development and progression of oral cancer.
  • Understanding m6A's role provides novel therapeutic targets for improving oral cancer treatment.
  • Targeting m6A pathways may enhance chemotherapy efficacy and inform new immunotherapy approaches.
Keywords:
RNA modifiedm6A autophagymetastasisoral cancerproliferation

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