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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro
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Celiac disease and bone.

Ananya V Kondapalli1, Marcella Donovan Walker2

  • 1Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Archives of Endocrinology and Metabolism
|November 16, 2022
PubMed
Summary
This summary is machine-generated.

Celiac disease (CD) is an autoimmune disorder linked to metabolic bone disease and increased fracture risk. While a gluten-free diet improves bone density, risks may persist, necessitating further research for optimal management.

Keywords:
Microarchitecturebone densityfracturegluteninflammation

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Area of Science:

  • Gastroenterology and Hepatology
  • Endocrinology
  • Rheumatology

Background:

  • Celiac disease (CD) is an autoimmune disorder triggered by gluten, often presenting with extra-intestinal manifestations like metabolic bone disease.
  • Metabolic bone disease in CD is associated with an increased risk of fractures, though underlying mechanisms require further elucidation.
  • Proposed mechanisms include nutrient malabsorption, inflammatory cytokine effects, hypogonadism, and malnutrition, all contributing to bone loss.

Purpose of the Study:

  • To review the current understanding of metabolic bone disease in celiac disease.
  • To discuss the impact of CD on bone mineral density and fracture risk.
  • To highlight the need for standardized screening and treatment guidelines for bone disease in CD patients.

Main Methods:

  • Literature review of studies investigating bone health in celiac disease patients.
  • Analysis of proposed mechanisms contributing to bone disease in CD.
  • Evaluation of the efficacy of gluten-free diet and potential osteoporosis therapies.

Main Results:

  • Most studies report reduced bone mineral density and deteriorated bone microarchitecture in CD patients.
  • An increased fracture risk is frequently observed in individuals with CD.
  • A gluten-free diet can improve bone mineral density, but levels may remain lower than in controls, and fracture risk can persist.

Conclusions:

  • Metabolic bone disease is a significant concern in celiac disease, contributing to fractures.
  • Current management with a gluten-free diet shows benefits but may not fully resolve bone density deficits or fracture risk.
  • Further research is essential to establish standardized guidelines for screening and treating metabolic bone disease in CD, identifying patients needing early intervention with osteoporosis therapies.