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Circulating Biomarkers in Hypertrophic Cardiomyopathy

Eldon L Matthia1, Michael L Setteducato1, Mohammed Elzeneini1

  • 1Department of Medicine University of Florida Gainesville FL.

Journal of the American Heart Association
|November 16, 2022
PubMed

Insights

Circulating biomarkers in hypertrophic cardiomyopathy (HCM) can help doctors diagnose, treat, and predict outcomes for this common genetic heart disease. This review covers key biomarkers related to HCM pathology and their clinical importance.

Area of Science:

  • Cardiology
  • Genetics
  • Biochemistry

Background:

  • Hypertrophic cardiomyopathy (HCM) is the most prevalent genetic heart disease.
  • Biomarkers, measurable in blood, offer potential for clinical decision-making in HCM.
  • Understanding pathological processes in HCM is crucial for effective management.

Purpose of the Study:

  • To provide an updated review of circulating biomarkers in hypertrophic cardiomyopathy (HCM).
  • To correlate biomarkers with key pathological processes in HCM.
  • To discuss the clinical significance of these biomarkers for diagnosis, treatment, and prognosis.

Main Methods:

  • Literature review of circulating biomarkers in HCM.
  • Categorization of biomarkers based on underlying pathological mechanisms.
  • Analysis of clinical utility and significance of identified biomarkers.

Main Results:

  • Identified key circulating biomarkers associated with HCM.
  • Highlighted biomarkers reflecting wall stretch, myocardial necrosis, fibrosis, inflammation, hypertrophy, and endothelial dysfunction.
  • Summarized the clinical relevance of these biomarkers in managing HCM patients.

Conclusions:

  • Circulating biomarkers play a vital role in understanding and managing hypertrophic cardiomyopathy.
  • These biomarkers can aid clinicians in diagnosis, treatment selection, and outcome prediction.
  • Further research into biomarker panels may enhance personalized medicine approaches for HCM.

Keywords:
biomarkercardiac imaginghypertrophic cardiomyopathy

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