Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

71.5K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
71.5K
Acute Pharyngitis01:30

Acute Pharyngitis

1.3K
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
1.3K
DNA Bacteriophages01:26

DNA Bacteriophages

98
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
98
Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

62.9K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
62.9K
Chronic Pharyngitis01:23

Chronic Pharyngitis

4.0K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
4.0K
Viral Replication: Lysogenic Cycle01:16

Viral Replication: Lysogenic Cycle

130
The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects...
130

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing imatinib sampling strategies through a population approach: a crucial step to model-informed precision dosing validation for point-of-care therapeutic drug monitoring.

BMC pharmacology & toxicology·2026
Same author

Diagnostic and prognostic relevance of valve strands in patients with suspected infective endocarditis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

Mind the Gap: Inadequate Performance of Embolic Risk Scores in Infective Endocarditis.

Open forum infectious diseases·2026
Same author

Evaluating Bayesian Vancomycin Dosage Adjustment in Neonates: A Simulation-Based Virtual TDM Study.

Clinical pharmacokinetics·2026
Same author

Pelargonium sidoides extract (EPs® 7630) versus usual care for acute bronchitis in Swiss primary care (PHYTOBRONCH): a pragmatic, open-label, randomised controlled trial.

NPJ primary care respiratory medicine·2026
Same author

Case Report: Transverse myelitis following CAR-T cell therapy for post-transplant lymphoproliferative disorder.

Frontiers in immunology·2026

Related Experiment Video

Updated: Aug 21, 2025

Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos
11:20

Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos

Published on: May 12, 2020

6.6K

[Phage therapy for respiratory infections].

Georgia Mitropoulou1, Pieter-Jan Gijs1, Angela Koutsokera1

  • 1Service de pneumologie, Département de médecine, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.

Revue Medicale Suisse
|November 16, 2022
PubMed
Summary

Antibiotic resistance is a global crisis. Phage therapy shows promise for bacterial infections, but more clinical trials are needed to prove its effectiveness and guide future treatments.

More Related Videos

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
09:23

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Published on: January 5, 2024

2.0K
Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice
08:46

Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice

Published on: January 26, 2024

1.8K

Related Experiment Videos

Last Updated: Aug 21, 2025

Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos
11:20

Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos

Published on: May 12, 2020

6.6K
Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
09:23

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Published on: January 5, 2024

2.0K
Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice
08:46

Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice

Published on: January 26, 2024

1.8K

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Bacteriophage Research

Context:

  • Antibiotic resistance poses a significant global health threat, especially for respiratory infections.
  • Bacteriophage therapy (phage therapy) is being re-evaluated as a potential treatment for bacterial infections.
  • Current evidence for phage therapy's effectiveness relies on case studies and preclinical data, lacking robust clinical trials.

Purpose:

  • To review the current status and future directions of phage therapy in combating antibiotic-resistant bacterial infections.
  • To highlight the need for standardized protocols in phage production and administration.
  • To emphasize the importance of translational studies for validating phage therapy.

Summary:

  • Phage therapy, using viruses that infect bacteria, is a potential alternative to antibiotics.
  • While appearing safe, its efficacy requires validation through controlled clinical trials.
  • Successful case reports and preclinical advancements are driving renewed interest in this therapeutic approach.

Impact:

  • Phage therapy could offer a viable solution to the growing problem of antibiotic resistance.
  • Standardization and further research are crucial for unlocking the full potential of phage therapy.
  • This approach may provide new treatment options for patients with difficult-to-treat bacterial infections, particularly respiratory ones.