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Enhancing Cellular Internalization of Single-Chain Polymer Nanoparticles via Polyplex Formation.

Naomi M Hamelmann¹, Sjoerd Uijttewaal¹, Sry D Hujaya¹

¹Department of Molecules and Materials, MESA+ Institute for Nanotechnology and TechMed Institute for Health and Biomedical Technologies, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.

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|November 16, 2022

Summary

This summary is machine-generated.

Researchers enhanced intracellular delivery of single-chain polymer nanoparticles (SCNPs) using a positive polymer to form polyplexes. This strategy improved nanoparticle uptake and cytosolic delivery for nanomedicine applications.

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Area of Science:

Nanomedicine
Polymer Chemistry
Cellular Biology

Background:

Intracellular delivery of nanoparticles is essential for effective nanomedicine therapeutics and imaging.
Single-chain polymer nanoparticles (SCNPs) offer a unique size range (5-20 nm) for nanocarrier applications.
Enhancing intracellular delivery of SCNPs is critical for their therapeutic potential.

Purpose of the Study:

To investigate the use of a positive polymer as a delivery agent to enhance intracellular delivery of SCNPs.
To characterize the polyplexes formed between SCNPs and the positive polymer.
To evaluate the cellular uptake and cytosolic delivery efficiency of SCNPs via polyplex formation.

Main Methods:

Formation of polyplexes between single-chain polymer nanoparticles (SCNPs) and a positively charged polymer.
Characterization of polyplex size and surface charge.
Confocal microscopy to visualize and quantify cellular uptake and cytosolic delivery of SCNPs.

Main Results:

Polyplex formation significantly enhanced the rapid cellular uptake of SCNPs.
Confocal microscopy confirmed the successful cytosolic delivery of SCNPs.
The potential of SCNPs as nanocarriers was demonstrated through doxorubicin conjugation.

Conclusions:

Positive polymer-mediated polyplex formation is an effective strategy to enhance SCNP intracellular delivery.
This approach facilitates rapid cellular uptake and cytosolic delivery of SCNPs.
SCNPs show promise as versatile nanocarriers for drug delivery applications.