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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
271
Obesity and chronic kidney disease
Zongmiao Jiang1, Yao Wang2, Xue Zhao1
1Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.
American Journal of Physiology. Endocrinology and Metabolism
|November 16, 2022
Summary
Obesity significantly drives chronic kidney disease (CKD) progression through complex mechanisms. Understanding these pathways is crucial for developing new treatments to slow kidney damage.
Area of Science:
- Nephrology
- Endocrinology
- Pathology
Background:
- Global obesity prevalence has tripled since 1975, posing a significant public health challenge.
- Obesity is increasingly recognized as a major factor contributing to the progression of chronic kidney disease (CKD).
- Mechanisms linking obesity to kidney disease include hemodynamic alterations, inflammation, oxidative stress, and renin-angiotensin-aldosterone system (RAAS) activation.
Purpose of the Study:
- To review the current understanding of the mechanisms driving obesity-related kidney disease.
- To outline the characteristic pathological changes observed in obesity-related kidney disease.
- To discuss future therapeutic strategies for managing this condition.
Main Methods:
- This review synthesizes existing research on obesity-related kidney disease.
- It examines the pathophysiological pathways involved.
- It discusses clinical manifestations and treatment outcomes.
Main Results:
- Obesity-related kidney disease typically presents with glomerulomegaly and glomerulosclerosis.
- Microproteinuria is a common early symptom, while nephrotic syndrome is rare.
- Weight loss and RAAS blockers show protective effects, but disease progression to end-stage renal disease remains a concern.
Conclusions:
- Comprehending the intricate mechanisms of obesity-related CKD is essential for therapeutic advancement.
- Further research is needed to develop novel strategies to halt or reverse kidney damage in obese patients.
- Targeting obesity-specific pathways may offer new avenues for CKD treatment.
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