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Related Concept Videos

Fatigue01:21

Fatigue

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
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Chronic Pancreatitis I: Introduction01:24

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Fatigue in Patients with Chronic Hepatitis C.

Ya-Wen Chen1, Chich-Hsiu Hung2,3

  • 1Department of Nursing, I-Shou University, Kaohsiung, Taiwan.

Clinical Nursing Research
|November 17, 2022
PubMed
Summary

Gender, education, BMI, and hemoglobin levels significantly impact fatigue in chronic hepatitis C patients undergoing antiviral therapy. Monitoring hemoglobin is crucial for managing patient fatigue during treatment.

Keywords:
antiviral therapychronic hepatitis Cfatiguehemoglobin

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Area of Science:

  • Hepatology
  • Internal Medicine
  • Clinical Research

Background:

  • Chronic hepatitis C poses significant health challenges, with fatigue being a prevalent and debilitating symptom.
  • Antiviral therapy, while effective, can influence patient well-being and symptom experience.

Purpose of the Study:

  • To identify factors associated with fatigue in chronic hepatitis C patients before and during antiviral treatment.
  • To understand the temporal relationship between treatment, physiological changes, and fatigue levels.

Main Methods:

  • Prospective, repeated-measures design involving 115 chronic hepatitis C patients.
  • Utilized the Brief Fatigue Inventory (BFI-C) and Pittsburg Sleep Quality Index (PSQI) for data collection.
  • Monitored Pegylated Interferon plus Ribavirin dosages and serum values (hemoglobin, ALT, AST) throughout 24 weeks of therapy.

Main Results:

  • Multivariate analysis revealed gender, educational level, BMI, and hemoglobin as significant determinants of fatigue.
  • A notable decrease in hemoglobin levels was observed, reaching its lowest point at week 12.
  • Declining hemoglobin levels correlated with increased fatigue, necessitating clinical attention.

Conclusions:

  • Specific demographic and physiological factors influence fatigue in chronic hepatitis C patients undergoing antiviral therapy.
  • Close monitoring of hemoglobin levels is essential for proactive fatigue management during treatment.
  • Healthcare providers should assess fatigue and intervene proactively when hemoglobin declines.