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Low sCD163/TWEAK Ratio at First Day After Acute Myocardial Infarction Associated with Adverse Cardiac Remodeling in

Mehmet Sait Altintas1, Nilnur Eyerci2, Orhan Karayigit3

  • 1Istanbul Research and Training Hospital.

Kardiologiia
|November 17, 2022
PubMed

Insights

A lower soluble CD163 (sCD163) to TWEAK ratio after myocardial infarction (MI) predicts adverse cardiac remodeling. This ratio shows higher diagnostic performance than individual markers for predicting left ventricular volume increase post-MI.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Myocardial Infarction Pathogenesis

Background:

  • Cardiac remodeling is a significant complication following acute myocardial infarction (MI).
  • Identifying early predictors of adverse remodeling (AR) is crucial for patient management.
  • The role of the sCD163/TWEAK ratio in post-MI cardiac remodeling remains to be fully elucidated.

Purpose of the Study:

  • To investigate the predictive role of the sCD163/TWEAK ratio in cardiac remodeling after first acute MI in non-elderly patients.
  • To assess the diagnostic performance of the sCD163/TWEAK ratio compared to individual markers.

Main Methods:

  • Forty-four non-elderly patients (40-64 years) with first ST-elevation MI were enrolled.
  • Cardiac magnetic resonance (CMR) imaging was used to assess adverse remodeling (AR) at 6 months post-MI.
  • Serum levels of sCD163 and TWEAK were measured at baseline, 2 weeks, and 6 weeks post-MI.

Main Results:

  • Patients who developed AR had significantly higher baseline sCD163 and TWEAK levels but a lower sCD163/TWEAK ratio compared to those without AR.
  • A lower sCD163/TWEAK ratio on day 1 post-MI was associated with increased left ventricular end-diastolic volume at 6 months.
  • The sCD163/TWEAK ratio demonstrated superior diagnostic performance for predicting AR compared to sCD163 or TWEAK alone.

Conclusions:

  • The sCD163/TWEAK ratio plays a significant role in the early pathogenesis of adverse cardiac remodeling post-MI.
  • A diminished sCD163/TWEAK ratio in the acute phase following MI serves as a valuable early indicator of subsequent adverse cardiac remodeling.

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